A. Prevalence
- i Regional
- ii Change Over Time
B. Populations at risk
- i Genetic associations
- ii Environmental associations
C. Socioeconomic impact of disease
- i Direct cost
- ii Indirect costs
- iii Quality of life
A. Anatomy, Histology, physiology, pathophysiology of:
- i Nose and paranasal sinuses
- ii Pharynx
- iii Ear/Eustachian Tubes
- iv Larynx/Trachea
- v Lungs
- vi Eye
- vii Skin
- viii Gastrointestinal tract
B. Basic physiology, pathophysiology, and principles of:
- i Mucociliary function
- ii Smell and taste
- iii Auditory/vestibular function
- iv Voice
- v Respiratory function
- vi Deglutition
- vii Ocular protection mechanisms
- 1 Naso–lacrimal function
- 2 Conjunctival function
- viii GI function
A. Basic components, concepts and applications pertinent to Allergy:
- i Immunology
- 1. Function
- a. General aspects
- i Recognition
- ii Surveillance
- iii Amplification
- iv Memory
- b. Triggers of the immune response
- i Allergens, haptens, epitopes, parasites, macromolecules
- c. Categories of response
- 2. Components
- a. Inflammatory cells
- i Macrophages (APC)
- ii Lymphoid
- 1 T–cells
- 2 B–Cells
- 3 Null cells
- iii Granulocytes
- 1 Mast Cells/basophils
- 2 Eosinophils
- 3 Neutrophils
- 4 Platelets
- b. Immunoglobulins
- c. Inflammatory mediators
- i Cytokines
- ii Chemokines
- iii Vasoactive amines
- iv Leukotrienes
- v Prostaglandins
- vi Complement
- ii Endocrinology
- iii Neurology
- iv Molecular cell biology
- v Genetics
B. Physiology and pathophysiology
- i Immunology
- 1. Cellular communication
- a. Direct contact
- b. Cytokine/Chemokine mediated
- 2. Inflammatory pathways
- a. Cellular
- i Microphage
- ii Granulocyte
- 1 Mast Cell/Basophils
- 2 Eosinophil
- b Non-cellular
- i Complement
- ii Arachadonic Acid cascade
- iii Other
- 3. Immune sensitization
- 4. Hypersensitivity (Gel and Coombs)
- a I
- b II
- c III
- d IV
- e V
- f VI
- ii Allergic response (Type I)
- 1 Allergy sensitization
- a Antigen processing
- b T-cell
- c B-cell
- d IgE
- e Mast cell
- 2 Subsequent exposure—trigger
- a Mast Cell
- i Antigen crosslinking
- ii Degranulation
- 1 Preformed mediators
- 2 Newly synthesized mediators
- 3 Cytokines
- b Early phase response
- c Late phase response
- d Priming
- iii Microbiology
- 1 Parasitology
- 2 Bacteriology
- 3 Virology
- 4 Mycology
- iv Endocrinology
- v Neurology
- vi Molecular cell biology
- vii Genetics
- viii Nutrition
A. Differential diagnosis of inflammatory disease:
- i Nose/paranasal sinus
- ii Otologic
- iii Laryngopharyngeal
- iv Tracheobronchial
- v Thoracic/Pulmonary
- vi Gastrointestinal
- vii Ocular
- viii Cutaneous
B. Immunologic disorders
- i. Allergic diseases
- 1. Allergic Rhinitis
- 2. Allergic conjunctivitis
- 3. Otologic disease
- a. Otitis media
- b. Meniere’s
- c. Otitis externa
- d. Eustachian tube dysfunction
- 4. Asthma
- 5 Dermatitis
- a. Eczema
- b. Contact
- c. Urticaria/Angioedema
- 6. Allergic laryngitis
- 7. Gastrointestinal
- a. Eosinophilic esophagitis
- ii Co-morbid conditions impacted by allergy
- 1. Rhinosinusitiss
- 2. Otitis media
- 3. Eustachian tube dysfunction
- 4. Disordered sleep
- 5. Laryngeal/pharyngeal/esophageal disorders
- 6. Asthma
- iii Immunodeficiency
- iv Autoimmune diseases
A. History
- i Symptoms
- 1. Onset, duration, severity
- 2. Triggers
- 3. Exacerbating or ameliorating factors
- ii Exposures
- 1. Temporal relationships
- a. Intermittent
- b. Persistent
- 2. Identifiable antigen
- a. Aeroantigens (Inhalants)
- b. Ingestants
- c. Contactants
- d. Injectants
- iii Co-morbid conditions
- 1. Rhinosinusitiss
- 2. Otitis media
- 3. Eustachian tube dysfunction
- 4. Disordered sleep
- 5. Laryngeal/pharyngeal/esophageal disorders
- 6. Asthma
- 7. Ocular
- iv Family/childhood history
B. Physical examination
- i Face
- ii Ears
- iii Nose/Paranasal sinues
- iv Oro/Nasopharynx
- v Laryngotracheal
- vi Pulmonary
- vii Skin
C. Adjunctive testing: Indications, limitations, and normal and pathologic findings:
- i Ears
- 1. Audiovestibular testing
- ii Nose
- 1. Acoustic rhinometry/rhinomanometry
- 2. Nasal cytology/biopsy
- 3. Nasal/paranasal sinus culture
- 4. Nasal endoscopy
- 5. Olfactory testing
- 6. Radiologic testing
- iii Larynx
- iv Pulmonary
- 1. Pulmonary function testing
- 2. Radiologic testing
- v Sleep
D. Allergy testing:
-
- i Antigen selection
- 1. Antigen characteristics
- a. Aeroallergen physical characteristics
- b. Biologic activity/potency
- c. Antigen cross reactivity
- d. Antigen extraction/standardization
- 2. Aeroallergen distribution
- a. Principles of distribution
- b. Local and Regional differences
- ii Aeroallergen tests
-
- 1. Expanded specific allergen testing
- a. In vivo
- i Principles of in vivo testing
- 1. Pathophysiology of the skin whealing response
- a. Immediate response
- b. Delayed response
- 2. Factors that affect the skin whealing response
- ii Specific methodologies
- 1. Percutaneous (Prick) testing
- a. Single percutaneous (prick) testing
- b. Multi percutaneous (prick) testing
- 2. Intradermal testing
- a. Single intradermal testing
- b. Intradermal dilutional testing
- 3. Blended techniques of in vivo testing
- 4. Scratch testing (mentioned only for historical purposes)
- 5. Provocation
- b. In vitro
- i Principles of in vitro testing
- ii Methodologies
- 2. Principles of the allergen screen
- iii Ingestants (Food Allergy)
- 1. History
- a. Food diary
- b. Anaphylaxis
- 2. Testing
- iv Injectants
- v Contactants
E. Immunologic Evaluation (including rheumatologic)
A. Environmental control
B. Pharmacotherapy/pharmacology
-
-
- i Antihistamines
- ii Decongestants
- iii Mast cell stabilizers
- iv Mucolytics
- v Leukotriene modifiers
- vi Corticosteroids
C. Dietary control
D. Immunotherapy
-
- i. Desensitization
- 1. Route of delivery
- a. Subcutaneous
- b. Mucosal (e.g., sublingual)
- 2. Mechanism of action/li>
- 3. Indications/contraindications
- 4. Antigen dosing
- a. Starting dose
- b. Escalation
- c. Maintenance
- d Withdrawal
- 5. Mixing of treatment vial
- 6. Duration of therapy
- 7. Outcomes of immunotherapy
- ii Monoclonal antibody